If you have been keeping dogs for quite some time, then you already know that pups can feed entirely on their mother’s milk until they are ready to transition to adult foods. Just like any other animal, initial milk, also known as colostrum, has the right nutrients required for growing a healthy puppy and boosting immunity. However, as advised by veterinarians, it may become necessary to provide your pets with healthy supplements for optimum growth if the said puppies have been orphaned or rejected by their moms. In light of that, the best puppy milk replacers are highly recommended to enhance good health in your lovely puppies.

More often than not, puppy milk replacers contain minerals, nutrients, and essential amino acids as well as a reasonable amount of carbohydrates and fats. These products are available in liquid or powder forms perhaps to match very closely the canine milk. Well, just like any other pet food industry, not all puppy milk replacers are created equally, implying that some are great while others are not.

Because you are looking to settle on nothing less than the perfect supplement, you will need to carry out extensive research on the best products. This can be an overwhelming task especially if it is your first time buying these items. Fortunately, we are here to help you out by unveiling a comprehensive list of the top ten best puppy milk replacers to consider in 2021.

Best Puppy Milk Replacer – [Reviews & Buyer’s Guide]

10. PetAg Puppy Milk Replacer by Esbilac

The PetAg Puppy Milk Replacer by Esbilac is a remarkable formula that brings happiness to your puppy. This industry-leading supplement is packed with excellent nutritive value, explaining why it is the best replacement for mother’s milk.

Besides dissolving as soon as it ingested, it is incredibly easy to digest. This highly palatable supplement is safe for puppies aged six weeks old or above and it never irritates the pet. Its sweet aroma makes it suitable for mixing with other puppy meals.


  • Style –liquid
  • Size –eight ounces
  • Ingredients –Water, soybean oil, condensed skim milk, and heavy cream as well as calcium carbonate, magnesium sulfate, salt, vitamin A supplement, niacin supplement, and vitamin E supplement among others

9. Hartz Powdered Puppy Milk Replacer

Whether you are keeping an orphaned or mother-rejected puppy, the Hartz Powdered Puppy Milk Replacer will come in handy. This product is formulated to precisely match the mother canine’s milk as it contains an optimal balance of minerals, nutrients, and other essential vitamins that supports development and growth during the formative first six weeks of a puppy’s life.

The quick-mix powder easily blends with room-temperature water for on the go feeding. It also features magnesium for muscle & heart health, calcium for strong bones, vitamin A for proper eye development, and linoleic acid for healthy coat & skin. Besides being great alternative milk for puppies, the Hartz Powdered Puppy Milk Replacer can also be used as food supplements for nursing and pregnant mothers as well as recuperating dogs.


  • Style –powder
  • Main ingredients –calcium, magnesium, linoleic acid, and vitamin A among others
  • Product weight -12 ounces

8. Multi-Milk Replacer

The Multi-Milk Replacer is undeniably one of the best puppy milk replacers with all the essential vitamins and minerals required for optimum growth. It features a 23/30 milk matrix, making it a medium-level lactose milk replacer in the Zoologic Milk Matrix System. Made in the USA, this product digests and dissolves quickly, hence the right choice when looking for a solution for instant energy and better health. The Multi-Milk Replacer is best suited for rescued and depleted dogs.


  • Size -5 pounds
  • Product dimensions -12.5 by 4.5 by 15.6 inches

7. Milk Powder For Puppies By PetLac

Milk Powder For Puppies By PetLac is arguably one of the best replacement milk for puppies thanks to its rich nutrient content.

The formula in this milk provides a growing pup with 29 percent protein and 28 percent fat, so they have sufficient energy. It has also been fortified with a blend of minerals and vitamins as well as Lactobacillus fermentum that yields essential acids to boost digestion.

When fed on a newborn pup, it helps it gain up to 858 kilocalories for every kilogram of the supplement digested. The beauty of this powdered replacer is that it can be mixed with warm water to get highly soluble liquid milk.


  • Style –powder
  • Net contents -10.5 ounces
  • Ingredients –dried whey product, maltodextrins, dried skimmed milk, vegetable oil, and sodium caseinate as well as L-arginine, ferrous sulfate, salt, taurine, DL-methionine, and monopotassium phosphate among others.

6. Well & Good Puppy Milk Replacer

Are you looking for an excellent milk replacer for newborn puppies with all the essential nutrients needed for growth and development? If the answer is YES, then perhaps you need to consider the Well & Good Puppy Milk Replacer.

This vet-formulated dog supplement is fortified with fats, proteins, and colostrum, which mimics the dog’s mother nourishing milk. Available in powder form, this product can be turned into typical milk for easy digestion by dissolving in room temperature water. While this supplement can be used for newborn puppies aged over six weeks, it can also be used to support lactating or pregnant dogs.


  • Item weight -15.2 ounces
  • Ingredients –dried whey, animal & vegetable fat, dried whey protein concentrate, spray dried egg product, and sodium caseinate as well as magnesium oxide, calcium sulfate, cobalt sulfate, and choline chloride among others

5. Esbilac Liquid Milk Replacer For Puppies -4 Pack

If you were advised by your vet to provide your puppy with liquid milk replacer, then the Esbilac Liquid Milk Replacer For Puppies might be the right choice. Available in a pack of four each weighing 11 ounces, this supplement is ideal for puppies up to six weeks of age.

Besides that, it is also excellent for adult dogs with eating challenges due to surgery or illness for the simple reason that the milk replacer is easy to digest. Moreover, it does not put unnecessary strain on the dog /puppy’s digestive system. This award-winning pup milk replacer is rich in the necessary minerals, vitamins, and proteins to ensure proper growth and development.


  • Item weight – 44 ounces
  • Ingredients –Water, soybean oil, calcium caseinate, cream, choline chloride, potassium chloride, tricalcium phosphate, dicalcium phosphate, and zinc sulfate as well as calcium carbonate, salt, vitamin D3 supplement, vitamin B12 supplement, folic acid, potassium iodide, and biotin among others.

4. Nutri-Vet Puppy Milk Replacement Powder

If you are seeking for the best puppy milk supplement, then you just need to try out the Nutri-Vet Puppy Milk Replacement Powder. It is one of the most affordable products out there in the market, and you will definitely like the quantity.

The supplement is exceptionally rich in all the essential nutrients that mimic the dog mom’s colostrum, making it ideal for puppies under the age of six weeks. With a delicate balance of vitamins, essential electrolytes, and antibody molecules, this milk replacer is also great for any dog size as well as the elderly, pregnant, and convalescing canines. This vet-formulated supplement produces excellent growth, weight gain, and development.


  • Size –three packs
  • Item weight -36 ounces
  • Ingredients –vegetable & animal fat, whey protein concentrate, sodium caseinate, dried whey, dried corn syrup, dried colostrum, and zinc sulfate as well as cobalt sulfate, magnesium oxide, calcium chloride, and lecithin among others

3. Esbilac Puppy Milk Replacer by PetAg

The Esbilac Puppy Milk Replacer by PetAg has everything you need to nurse a rejected or orphan puppy. This supplement contains ¾ ounces of Esbilac powder, Bene-Bac single-dose tube, and 2 ounces nurser bottle to relieve intestinal distress in your lovely puppy.

This industry-leading milk replacer is a complete source of nutrients, including vitamins and minerals. Its life-saving formula closely matches the bitch’s milk in energy and protein. The good news about this powder formula is that it is easy to mix with water.


  • Style –liquid
  • Size -5 ounces
  • Recommended age of use –up to six weeks old
  • Ingredients –all-natural with minerals, vitamins, and trace nutrients

2. Goat’s Milk Esbilac Powder Replacer for Puppies

The Goat’s Milk Esbilac Powder Replacer is the best choice for puppies with a sensitive digestive system because it dissolves and digests easily and quickly. Many pet vets agree that this supplement closely matches the milk produced by a bitch for the simple reason that it provides balanced nutrition for puppies.

With plenty of dried proteins, soybean oil, minerals, and vitamins, this formula provides your young dog with up to 900 kilocalories for every single kilogram of milk. Besides making puppies healthier and energetic, this powdered milk can be mixed with other dog foods so it can be offered to old dogs, convalescing canines, or those under post-surgical rehabilitation.


  • Style –powder
  • Size -150 grams (5.25 ounces)
  • Main components -40% fat and 33 % protein

1. Esbilac Puppy Milk Replacer by PetAg

The Esbilac Puppy Milk Replacer by PetAg is formulated to bring complete happiness to your puppy. Best suited for rejected or orphaned puppies up to the age of six weeks, this supplement is enriched with essential minerals and vitamins.

Available in a powder form, this replacer is easy to make up into liquid milk –just mix with room temperature water. Its formula features vegetable oils blend with dried milk and cream, giving the puppy all the vital fats and proteins it needs to develop, grow, and gain weight. This all-natural, no-perseverative, and highly palatable milk replacer is easily digestible. Because of that, it yields results almost immediately.


  • Style –powder
  • Size -5.1 pounds
  • Ingredients –vegetable oil, whey protein, casein, butterfat, dried skimmed milk, egg yolk, copper sulfate, and choline chloride as well as vitamin E supplement, vitamin A supplement, vitamin B12 supplement, and vitamin D3 supplement among others

Buying Guide How to Choose the Best Puppy Milk Replacer:

There are many reasons why you need to supplement your dog’s puppy with milk replacers. It may include cases where the puppy’s mom passes away or it rejects its baby. Sometimes the mom dogs are ill, rendering to produce insufficient milk. Other categories of dogs that may require milk replacer supplements include, but not limited to sick puppies, pregnant/nursing dogs, and sick or convalescing dogs.

All these circumstances necessitate that you provide your pet with the best puppy milk replacers. However, as we rightly stated in the introductory section, milk replacers are not created equally, and so the puppy’s owner should choose the very best. Well, how do you pick the right product from a list of hundreds of products? The solution is quite simple –have the below buying or choosing tips at your fingertips!

Factors to Consider When Choosing Puppy Milk Replacer:

The puppy’s age
The very first factor to consider when choosing the best puppy milk replacer is to consider the pet’s age. This is because some of the milk supplements out there in the market are ideal for a given age. For instance, the PetAg Puppy Milk Replacer by Esbilac is strictly for newborn pups up to six weeks of age. Therefore, knowing the age of your pet goes a long way in finding the perfect solution.

Probiotic bacteria
Unfortunately, most dog owners overlook the issue of probiotic bacteria when choosing the best puppy milk replacers. It is, however, a crucial point to note that pup’s stomach gets upsets frequently because their guts are still immature. The best milk supplement, therefore, is the one with friendly bacteria cultures that helps the intestines of the dog to break down the milk.

Nutrient contents
Since we are replacing dog mom’s milk with alternative solutions, the replacer supplement should at least mimic the milk of the bitch. In other words, it must contain all the essential nutrients required by a puppy to attain optimum development, growth, and weight gain. At the bare minimum, the best puppy milk replacer to choose should have a balanced mix of calories, proteins, fats, minerals, and vitamins. Always check at the product’s label to get an idea of what the supplement contains.

There you are and now you know some of the best puppy milk replacers to consider in 2021. We sincerely hope that the reviews we have discussed herein will help you choose a formula that best suits the dietary needs of your puppy.

All the named top ten products have the best quality ever. As a matter of fact, they have been approved and authorized by vets, hence safe for your little friend. More importantly, these nutritious formulae are highly soluble and easy to digest. You may now go for one of these puppy milk replacers and rest assured that it would bring life-changing and health benefits for your pup.